The problems of river water environment are more prominent in plain areas of river network area，so carrying out river health assessment can effectively guide the work practice.This paper took Wuxi city as an example to determine the weight of each index determined by means of combination empowerment，and then calculate the river health level.The results showed that the health grades of Lengdu port and Tongqiao port were medium，and the health grades of Beixingtang，Jiulihe，Xinhuabang and Qinshui river were good.The evaluation results are consistent with the actual investigation，which can provide experience and reference for the development of river health assessment in plain areas of river network.