Regional water network is an extension of national major water network，serving as a carrier and grasper to improve the macro allocation of water resources in the national water network and systematic solution of regional water security issues. Currently，the planning concept，construction principles，and technical requirements of regional water network are still in the exploratory stage. Based on the requirements for water safety assurance in the new era，a construction approach for regional water network is proposed from optimizing the spatial layout of water network，enhancing the resilience of water source engineering systems，reserving high-quality development flexibility space，coordinating the construction of water network at all levels，exploring the comprehensive utilization efficiency of water network，and improving the digitalization and intelligence level of water network. A case study of water network planning in Jiangxi province is also conducted. The research results can provide reference for the planning and construction of regional water network in the new era.