A water and fertilizer integrated anti-blocking irrigation system of biogas slurry was proposed, popularized and applied in the orange orchard of Luofang biogas station in Xinyu of Jiangxi province. The results showed that there was no obvious loss of flow, and the original efficiency can still be maintained after a long time of operation. The biogas slurry filtration system can remove large, medium and small solid particles well, which was not easy to block, ensuring that the treated biogas slurry meets the normal growth and use of crops. Using the water and fertilizer integrated antiblocking irrigation system of biogas slurry, the amount of fertilizer was reduced by 50% per mu on average, the yield of orange was increased by 2.8% per mu on average, the economic benefit of saved cost and added income can reach 245.5 yuan per mu on average. The economic benefit was remarkable. The water and fertilizer integrated anti-blocking irrigation system of biogas slurry was suitable for popularization and application in southern orchards.