In this study，based on the operation of Three Gorges reservoir，combined with the engineering geological conditions of Xituo landslide，the seepage of the landslide was simulated with saturated -unsaturated method by the secondary development of FLAC 3D.Considering the reservoir regulation，the stability of Xituo landslide was evaluated by the strength reduction method.The results of this study will provide a scientific basis for the slope long-term monitor and treatment.