The phenomenon of uplift deformation in dam foundation and the mountains near dam is relatively rare at home and abroad.It is a new research topic to reasonably analyze the cause mechanism of uplift deformation and evaluate the safety impact of uplift deformation on water resources and hydropower engineering.Based on the theory of fluid-solid coupling，and considering the effect of seepage force under the condition of water storage，three-dimensional numerical simulation method was used to study the influence of deformation modulus and permeability coefficient of rock mass on uplift deformation in dam foundation and the mountains near dam.The results show that the amount of uplift deformation decreases with the increase of the deformation modulus of the rock mass，and the maximum uplift occurs in the downstream dam body.Larger uplift deformation may cause local landslide of the reservoir bank.Under the same relative permeability coefficient，the smaller the permeability coefficient of aquifer is，the larger the lift is.Under the condition of constant permeability coefficient of aquifer，with the change of permeability coefficient，the sensitivity of deformation to rock mass permeability coefficient is less than that of deformation modulus.The formation of “interface” of displacement deformation may cause the shear deformation of rock and hydraulic structure.