This paper finds out four factors of affecting Xinjiang Akto county’s water quality safety and five problems in the supervision system of water quality and safety testing according to investigation, analysis, demonstration and research on the water quality of safety drinking water in Akto county. Combined with the actual situation of the local situation, this paper puts forward the solution and improvement measures which have the guiding significance and reference value to construction of drinking water safety projects and establishment and implementation of disease prevention of water quality testing center.