Taking the Zhaitouli-Huangdijia Water Diversion Project，part of the first-phase urban-rural water supply integration project in Ninghua County，as the research object，this paper elaborates on the design and application of the integrated ventilation-dust removal-monitoring technology to address technical challenges in long-distance water diversion tunnel construction，such as difficulties in ventilation and smoke exhaust，dust pollution，and complex geological conditions.By adopting a ventilation scheme dominated by forced ventilation，dust removal measures such as wet drilling and spray dust reduction，as well as monitoring technologies for geology，support，harmful gases，and dust，and establishing an integrated collaborative mechanism，the effectiveness of ventilation and dust removal has been effectively improved，the health and safety of construction personnel have been guaranteed，the construction progress has been significantly accelerated，and the effective collaborative control of project cost，quality，and schedule has been realized.This provides a promotable successful example and technical reference for long-distance water diversion tunnel construction.